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KMID : 0378120020290020099
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Chungnam Medical Journal
2002 Volume.29 No. 2 p.99 ~ p.105
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A study of Lithium-associated Subclinical Hypothyroidism
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Kim Jeong-Lan
Lee Sun-Woo
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Abstract
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Lithium is a mainstay in the treatment of bipolar disorder. It is well-known to suppress thyroid function varying from overt hypothyroidism to subclinical, or asymptomatic hypothyroidism. While lithium-induced overt hypothyroidism has been well studied. subclinical hypothyroidism is less well understood. Thus, this paper has two aims : (1) to evaluate the effect of lithium and clinical features in patients with bipolar I disorder who are taking lithium maintenance therapy and (2) to review subclinical hypothyroidism.
We included 2% patients(men : 9, women : 13). who met criteria for bipolar I disorder in DMS-Ⅳ and are taking lithium as mood stabilizer. Five with subclinical hypothyroidism were identified after examination of T3. T1. and TSH(thyroid stimulating hormone). However. we did not find any difference in clinical variables. such as age. sex. subtype of bipolar disorder. or exposure duration of lithium. between patients with subclinical hypothyroidism and patients with euthyroid. we suggest that lithium-induced subclinical hypothyroidism can be underdiagnosed in practice in spite of interfering the treatment of bipolar disorder. Further systematic and well-designed studies are needed in the future.
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KEYWORD
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Lithium, Subclinical hypothyroidism, Bipolar disorder
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